Epigenomics
Authors: Samira Tarashi, Sara Ahmadi Badi, Arfa Moshiri, Nayereh Ebrahimzadeh, Abolfazl Fateh, Farzam Vaziri, Hossein Aazami, Seyed Davar Siadat & Andrea Fuso
Epigenetics regulate gene function without any alteration in the DNA sequence. The epigenetics represent one of the most important regulators in different cellular processes and have initially been developed in microorganisms as a protective strategy. The evaluation of the epigenetic mechanisms is also important in achieving an efficient control strategy in tuberculosis (TB). TB is one of the most significant epidemiological concerns in human history. Despite several in vivo and in vitro studies that have evaluated different epigenetic modifications in TB, many aspects of the association between epigenetics and TB are not fully understood. The current paper is aimed at reviewing our knowledge on histone modifications and DNA methylation modifications, as well as miRNAs regulation in TB.
Keywords: DNA methylation, epigenetic modification, histone, miRNA, Mycobacterium tuberculosis