Tuberculosis: Integrated Studies for a Complex Disease
Authors: Samira Tarashi, Mir Davood Omrani, Arfa Moshiri, Abolfazl Fateh, Seyed Davar Siadat, Andrea Fuso
Tuberculosis (TB) infection still represents a relevant global health issue affecting millions of patients worldwide, although some may remain undiagnosed and untreated. The diagnosis, treatment, and control strategies of TB may not be as effective as they should be. In this regard, the role of the microbiota community and epigenetic mechanisms in TB infection can be fundamental but not widely deciphered. It appears that the development of microbiota and epigenetics analysis can be operative for innovative and more effective control strategies and targeted therapeutics of TB infection. Hence, an overview of the correlation between microbiota community and epigenetic mechanisms occurring upon TB infection can represent an opportunity to improve control of TB infection while stressing that additional evaluations are necessary to uncover this correlation.